Screening Potential Biomaterials of Ti- and Zr-Based Metallic Glasses Rapidly
نویسندگان
چکیده
Corrosion phenomenon is the important factor in the field of biomaterial applications. The corrosion resistance of the metallic glasses was investigated by the cyclic voltammetry and a low-voltage potential state test of the cell membrane potential simulation in the simulation body fluid Hank’s solution in this paper. The potential Tiand Zr-based metallic glasses were screened rapidly to test the cytotoxicity of the metallic glasses. Ti40Zr40Si15Cu5, Ti42Zr40Ta3Si15, Ti45Zr40Si15 and Zr50Ti35Si15 of 9 metallic glasses composition showed superior corrosion resistance and electrochemical stability. The metallic glasses with the higher Cu content exhibited electrochemical current responses. Cytotoxicity of the metallic glasses and the medium of the metallic glasses after the potential state test were made a study by the in-vitro MTT test further. The cell viability test results showed the solid specimens and the medium after the potential state test of Ti40Zr40Si15Cu5, Ti42Zr40Ta3Si15, Ti45Zr40Si15 and Zr50Ti35Si15 have no significant cytotoxicity for murine bone marrow stem cells. In this study, the metallic glasses with high Ti and Zr content (> 80%) and low Cu content (≦ 5%) for the cell tissue have excellent electrochemical stability and low cytotoxicity by rapid electrochemical tests and they are potential biomaterials for biomedical applications.
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